Pathogenesis

The cause of the disease is unknown. Of great importance is genetic predisposition, genetic marker which is the antigen HLA B 27, occurring in 90-95% of patients, 20-30% of their first-degree relatives and in only 7-8% in the population. It is believed that the gene sensitivity ankylosante spondylitis is coupled with the gene HLA B 27.

There are two theories of pathogenesis, explaining the important role of HLA B 27 in the development of Ankylosing Spondylitis  's disease. According to the theory of receptor antigen HLA B 27 is a receptor for the damaging etiological factor (eg, bacterial antigen, virus, artritogennogo peptide, etc.). The resulting complex leads to production of cytotoxic T-lymphocytes, which can then damage the cells or tissue area, where the molecules of the antigen in 27.

According to the theory of molecular mimicry bacterial antigen, or any other damaging agent in combination with other HLA molecule can be similar to the HLA B 27 properties and identify cytotoxic T-lymphocytes as HLA B 27 or reduce the immune response to peccant peptide (the phenomenon of immune tolerance) .

As a result, developing immunovospalitelny process. Usually it begins with the defeat of the sacroiliac joint, and then involved intervertebral, costovertebral, rarely - peripheral joints. First is infiltration by lymphocytes and macrophages, and then develop active fibroplastichesky process with the formation of fibrous scar tissue, which undergoes calcification and ossification.
The main pathological manifestations of Ankylosing Spondylitis  's disease are inflammatory enthesiopathies (inflammation of the place of attachment to the bone tendons, ligaments, fibrous part of the intervertebral discs, capsules of the joints), inflammation of the bones forming the joint (osteitis), and synovitis.

In the subsequent develop fibrous and bony ankylosis of the joints of the axial skeleton, at least - of the peripheral joints, comes early ossification of the ligamentous apparatus of the spine.

Latest Ankylosing Spondylitis Blog Posts

• Ankylosing Spondylitis – Force Attacked More When It’s Cold
  
  If someone truly suffers from the low temperatures characteristic of the winter season are those with Ankylosing Spondylitis (75% of cases are in women) because their ailments are heightened considerably. Rheumatic diseases have accompanied humans almost since its appearance on our planet and are aware of this anthropological studies of Java man who inhabited the Earth [...]


• Ankylosing Spondylitis And Pregnancy
  
  In people with psoriatic arthritis and rheumatoid arthritis disease symptoms improve in pregnancy (8 to 10 women have less arthritis in pregnancy). But that does not happen in most people with ankylosing spondylitis. People that really show the improvement of symptoms in ankylosing spondylitis most likely also have psoriasis or inflammatory bowel disease. The study: A [...]

Ankylosing Spondylitis News

Disabled cyclist takes matters into his own hands - USA TODAY Disabled cyclist takes matters into his own hands USA TODAY By the time a specialist diagnosed an incurable form of arthritis called ankylosing spondylitis, also known as AS, much of the damage had been done. The pain subsided and he learned to walk again, but with an awkward gait. "I don't have any movement in ... and more » A Pain in the Back - dailyRx A Pain in the Back dailyRx It is called ankylosing spondylitis, and it is a pain in the back. Ankylosing spondylitis is a type of arthritis that mainly affects the the spine, but can also affect other joints. It causes joints to become inflamed, leading to pain and discomfort.